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domain	thegpm.org
summary	Here’s a summary of the website content: The text discusses splice variants of genes, specifically highlighting the cases of DUT:p and LEPR:p. DUT:p utilizes a splice variant that eliminates the targeting peptide while preserving the enzymatic function through exon substitution. Conversely, LEPR:p, a previously promising drug target, ultimately proved problematic and contributed to the decline of protein engineering efforts in the late 80s/early 90s due to issues with its ligand.
title	THE GPM
description	THE GPM
keywords	sequence, protein, splice, human, exons, canon, exon, data, folly, form, proteomics, peptide, tissue, terminal, variant, have, peptides
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nslookup	A 24.76.97.129
created	2026-03-09
updated	2026-03-09
summarized	None