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domain	oncnursingnews.com
summary	Key Points from the Article: 1. Study Overview: - A clinical trial investigated whether adding pembrolizumab (a checkpoint inhibitor) to Bacillus Calmette-Guérin (BCG) could improve outcomes in patients with high-risk nonmuscle-invasive bladder cancer. 2. Key Findings: - EFS Outcome: The overall first-line efficacy (EFS) rate was not significantly higher when atezolizumab (the investigational drug) was added to BCG compared to BCG alone. - Radiographic Response Rate: There was a modest increase in the radiographic response rate with the addition of pembrolizumab, but this improvement did not translate into enhanced clinical outcomes. 3. Implications for Clinical Practice: - The data suggest that adding atezolizumab to BCG does not confer additional benefit in terms of overall first-line efficacy or progression-free survival. - Clinicians should continue to rely on standard treatments like BCG, as the added complexity and potential toxicity from a dual therapy regimen do not appear to provide clear clinical advantages. Conclusion: The study concludes that pembrolizumab does not improve outcomes when combined with BCG in high-risk nonmuscle-invasive bladder cancer. Current evidence supports sticking with standard treatment approaches for this patient population.
title	Oncology Nursing News – Clinical Insights for Cancer Care Nurses
description	Oncology Nursing News connects oncology nurses and APPs with updates on therapy advances, side effect management, and patient-centered cancer care.
keywords	view, more, cancer, video, treatment, multimedia, oncology, practice, connections, community, management, november, cell, patient, strategies, breast, lung
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nslookup	A 76.76.21.21
created	2025-11-09
updated	2025-11-25
summarized	2025-11-26

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